Clik here to view.
A Sirtuin Activator Extends Lifespan in Normal Mice
If you haven’t seen it, the Sinclair group and numerous co-workers at the NIH and elsewhere now report that the SIRT1 activator SRT1720 extends the lifespan of mice on a diet of normal chow, and they...
View ArticleYoung Blood
Anti-aging studies, when they make the news, fall into three unequal categories. There’s a vast pile of quackery, which mercifully isn’t (for the most part) newsworthy. There are studies whose...
View ArticleGoogle’s Calico Moves Into Reality
Google’s Calico venture, the company’s out-there move into anti-aging therapy, has made the news by signing a deal with AbbVie (the company most of us will probably go on thinking of as Abbott). That...
View ArticleIbuprofen For a Longer Life?
Here’s one that I didn’t expect: a report that ibuprofen extends lifespan in model organisms. Here we show that ibuprofen increased the lifespan of Saccharomyces cerevisiae, Caenorhabditis elegans and...
View ArticleClik here to view.
Rapamycin And Aging: The Spotlight Shines
Rapamycin gets the spotlight in Bloomberg Businessweek here. This is a look at what’s been set in motion by the 2009 report that the compound notably extended the life of rodents in long-term feeding...
View ArticleMetformin for Aging in General?
Here’s an interesting report in the Wall Street Journal on plans to run a large clinical trial with metformin. That compound has a lot of effects, and many of them seem as if they could be beneficial...
View ArticleA Young Blood Controversy
The recent revival of interest in the way that the blood from younger animals (and people?) can improve the health of older ones came bundled with a particular protein candidate for the effect, GDF11....
View ArticleAging As a Disease
I’ve mentioned numerous times around here that therapies directed against aging in general have a rough regulatory outlook. The FDA, in general, has not considered aging a disease by itself, but rather...
View ArticleAnother Longevity Target
Add another potential target to the longevity list: this paper in Cell (open access, actually) provides evidence that the well-known Ras-ERK-ETS pathway is also involved in lifespan. This is work in...
View ArticleYoung Blood, Revisited
Here’s an update on the state of those studies that showed that infusing blood of younger animals into olders ones reversed some effects of again. Human studies are underway – small, but worth keeping...
View ArticleThe First Real Anti-Aging Trial in Humans
I’ve mentioned the proposed clinical trial with metformin as a general anti-aging therapy. Here’s a profile of Nir Barzilai, the principle investigator for it. Choosing metformin was as much about...
View ArticleA Nobel for DNA Repair
This year’s Nobel Prize in Chemistry goes to Tomas Lindahl of the Crick Institute, Paul Modrich of Duke/Howard Hughes Medical Institue and Aziz Sancar of UNC – Chapel Hill, for mechanisms of DNA...
View ArticleThe Samumed Story
Biopharma can be a weird place. Breakthroughs happen, although not as often as the press releases would have everyone believe, and we certainly don’t always see them coming. So when word comes of some...
View ArticleSubtle Changes Can Be Yours, for Fifty Dollars a Month
Several people have sent me a link to Elysium Health, and I can’t say that it’s improved my morning. This is a supplement company founded by (among others) Leonard Guarente of MIT, who is of course...
View ArticleA Shady Trial?
The “young blood” research field is moving right along, but there are reasons to wonder about some of the directions it’s moving in. I’m referring, of course, to the results that have shown profound...
View ArticleIsotopes, Get Your Revivifying Isotopes
Here’s your chance to get in on the ground floor – at least, the ground floor of a pitch you probably haven’t heard before. The chemists and biologists in the crowd will be familiar with how isotopic...
View ArticleCellular Rejuvenation, For Real
There’s been a good amount of coverage of this paper, which is certainly worth a read. It concerns the “Yamanaka factors”, four proteins whose expression seems to be key for induced pluripotent stem...
View ArticleVCAM1 As a Player in the Aging Brain
Possible intervention targets for age-related degeneration are always welcome, particularly when they come bearing experimental evidence, and even more so when they relate to the central nervous...
View ArticleMetformin and Exercise
I’ve written about metformin quite a few times over the years on the blog, and for several reasons. It is (for starters) obviously a frontline drug for treatment of Type 2 diabetes, a condition that...
View ArticleYoung Blood and Old Blood
So let’s do a non-coronavirus post for the weekend. Over the years, I’ve sporadically reported on the (rather contentious) field of aging and its biochemical implications. Many readers will recall the...
View Article